Research Associate/Senior Research Associate, Epigenetics

To restore cell health and resilience through cellular rejuvenation programming to reverse disease, injury, and the disabilities that can occur throughout life.

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Who You Are

The successful applicant will work collaboratively with experimental and computational members of the Reik group in Altos. The Research Associate/Senior Research Associate will support and assist a highly collaborative, innovative team in the Cambridge Institute of Science focused on understanding chromatin mechanics in cellular aging and rejuvenation.

• Bring a can-do attitude that approaches problems and opportunities with curiosity and creativity.
• Be attentive to detail with excellent time management, multi-tasking, and prioritisation skills.
• Thrives in collaborative environments, thinks pragmatically, works flexibly, and uses good judgement.
• Be committed to fostering an inclusive and diverse workforce that enables all participants to contribute to their full potential in pursuit of organisational objectives.
• Be excited about the Altos mission of investigating cellular rejuvenation programming to restore cell health and resilience, with the goal of reversing disease to transform medicine.
• Have a growth mindset - desire to constantly expand your skill set and knowledge and that working with others is an opportunity for growth. Keen to learn more about biology, computational science, and medicine.
• Strong hands-on experience with cell culture, molecular biology methodologies, including, chromatin preparation, DNA/RNA extraction, PCR.
• Experience in working collaboratively within a team.
• Positive attitude to taking new challenges, learning new skills and being highly adaptable.
• Experience of consistently delivering high-quality performance under tight schedules.

• Results Oriented
• Self-Awareness
• Excellent Teamwork and Collaboration skills
• Excellent Listening skills
• Strategic Agility
• Dealing with Ambiguity

• Generation, maintenance, and cryo-perseveration of various cell lines, including stem cells.
• Perform in vitro reprogramming of adult somatic cells.
• Assist the team characterize the chromatin landscape of somatic cells undergoing reprogramming.
• Perform various in vitro analysis experiments; chromatin preparation, protein and nucleic acid isolation, Western blotting, fluorescence microscopy, biochemical assays, and data generation.
• Carry out risk assessments in accordance with the institute's Health and Safety policies covering all aspects of laboratory work.
• Maintaining accurate and up-to-date electronic records of all lab activities.
• Assist with reviewing research activities to determine where new information, methods, or collaborations could positively impact projects and improve efficiency of processes.
• Assisting with the development of innovative techniques and systems needed to meet the team's research goals.
• Interfacing on a regular basis with the lead scientist to present, organize, coordinate, and execute experimental work.

Minimum Qualifications

BSc/MSc (or equivalent) in a biology-based discipline.

Preferred Qualifications

• Experience and/or familiarity of generating iPSCs.
• Experience with generating and QC of sequencing libraries.
• Experience and/or familiarity with single cell sequencing technologies.
• Experience with fluorescence microscopy and image analysis.

The salary ranges for this position are: Research Associate I range is £29,750 to £40,250; Research Associate II range is £33,150 to £44,850; Senior Research Associate range is £39,950 to £54,050

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