Research Scientist – Protein Scientist

Company Description
Bicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines. Our pipeline includes Bicycle Toxin Conjugates® as well as fully synthetic Bicycle® systemic immune cell agonists and Bicycle tumor-targeted immune cell agonists (Bicycle TICAs) focused on oncology indications with high unmet medical need. Bicycle is headquartered in Cambridge, UK, and our US operations run out of Lexington, MA.
Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
• We are One Team. We only succeed when we work together.

Job Description
We have an exciting opportunity for a highly skilled Research Scientist to join our Protein & Cellular Sciences Team: You will join a small team dedicated to acquisition and production of high-quality recombinant protein material to facilitate the Bicycle discovery platform.
We are searching for an enthusiastic and self-motivated individual who is passionate about making proteins. You will enjoy spending significant time at the bench but are also looking for opportunities to directly contribute to projects outside the laboratory. You will be someone who understands the principles of protein expression and purification and are looking to expand your knowledge with challenging targets.
This role would be particularly well suited to a flexible individual who enjoys working in a dynamic working environment solving problems in a methodical manner, both individually and as a part of a group.
KEY RESPONSABILITIES

• Support multiple Discovery campaigns by acting as key point of contact for protein reagent provision
• Research target biology and identify necessary reagents to progress programs
• Design, express, and purify recombinant proteins using eukaryotic & prokaryotic systems
• Analyse samples in our protein quality control process using techniques such as BLI, mass spectrometry, SDS-PAGE & SEC-MALS.
• Independently problem-solve, troubleshoot, and identify next steps and solutions
• Present interpreted data and conclusions effectively in oral or written form to relevant parties, including possible next steps to drive projects forward
• Interact and communicate efficiently in a collaborative environment involving cross-functional teams of biologists and chemists

Qualifications*
Essential:*

• Relevant academic or industry experience with a focus on protein science
• Understanding of molecular biology and protein production from eukaryotic and prokaryotic systems
• Practical experience in protein purification with AKTA systems (affinity chromatography and SEC)
• Hands-on experience of a range of biophysical and/or biochemical assay techniques to enable quality control of proteins (SDS-PAGE, BLI, SPR and SEC-MALS)
• Ability to adapt work to facilitate delivery to timelines, problem-solve, troubleshoot and identify next steps and solutions
• Strong interpersonal skills along with data presenting & reporting
• Diligent in documenting work and adherent to data integrity requirements

Desirable:

• A PhD in Biochemistry or a related discipline with a focus on protein science (or equivalent qualification/experience)
• Experience in a biotech or industrial environment
• Experience with other chromatography techniques (HIC, IEC etc.)
• Ability to interpret mass spectrometry data
• An understanding of structural biology
• An understanding of phage display or other display technologies

Additional Information

• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Flexible working environment
• Competitive reward including annual company bonus
• Employee recognition schemes
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
• Employer contribution to pension (employee does not have to contribute)
• Life assurance cover 4x basic salary
• Private Medical Insurance, including optical and dental cover
• Group income protection
• Employee assistance program
• Health Cash Plan
• Access to company subsidized gym membership
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
• Cycle to work scheme

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.

Job Type: Full-time